HHAL MEDICAL NEWS SEPTEMBER 2012
The
Key to Longevity After Age 75?
Don't smoke, have rich social interactions, and engage in leisure activities.
Rizzuto D et al. BMJ
2012 Aug 30; 345:e5568
Non-Alcoholic Red Wine
Lowers Blood Pressure
Non-alcoholic
red wine was found to lower blood pressure in men at high risk of heart disease, researchers from Spain reported in the journal
Circulation Research. The authors explained that the men who drank non-alcoholic red wine daily for four weeks
had higher levels of nitric oxide in their blood. Nitric oxide helps lower both systolic
and diastolic blood pressure- the molecule helps blood vessels relax, allowing more blood to reach the body's organs,
including the heart.
http://www.medicalnewstoday.com/printerfriendlynews.php?newsid=250000
Even
In Normal Range, High Blood Sugar Linked To Brain Shrinkage
People whose blood sugar is on the high
end of the normal range may be at greater risk of brain shrinkage that occurs with aging and diseases such as dementia, according
to new research published in the September 4, 2012, print issue of Neurology®, the medical journal of the American Academy
of Neurology.
"Numerous studies have shown a link between type 2 diabetes
and brain shrinkage and dementia, but we haven't known much about whether people with blood sugar on the high end
of normal experience these same effects," said study author Nicolas Cherbuin, PhD, with Australian National University
in Canberra.
The study involved 249 people age 60 to 64 who had blood sugar in the normal range as defined by
the World Health Organization. The participants had brain scans at the start of the study and again an average of four years
later.
Those with higher fasting blood sugar levels within the normal range and below 6.1 mmol/l (or 110 mg/dL)
were more likely to have a loss of brain volume in the areas of the hippocampus and the amygdala, areas that are involved
in memory and cognitive skills, than those with lower blood sugar levels. A fasting blood sugar level of 10.0 mmol/l (180
mg/dL) or higher was defined as diabetes and a level of 6.1 mmol/l (110 mg/dL) was considered impaired, or prediabetes.
After controlling for age, high blood pressure, smoking, alcohol use and other factors, the researchers found that
blood sugar on the high end of normal accounted for six to 10 percent of the brain shrinkage.
"These findings
suggest that even for people who do not have diabetes, blood sugar levels could have an impact on brain health," Cherbuin
said. "More research is needed, but these findings may lead us to re-evaluate the concept of normal blood sugar levels
and the definition of diabetes."
http://www.medicalnewstoday.com/printerfriendlynews.php?newsid=249827
Stress Can Cause People To Retain As Much Salt As Eating French Fries.
When African American individuals are stressed, they
tend to keep about 160 milligrams of salt, and their normal top blood pressure number increases by about 7 points.
Top blood pressure numbers represent the pressure inside blood vessels every time the heart beats.
http://www.medicalnewstoday.com/printerfriendlynews.php?newsid=250003
Green
Tea Improves Memory And Spacial Awareness
Although previous studies have shown that green tea consumption aids in weight loss, can lower cholesterol
levels and is full of anti-oxidants, a new report published in Molecular Nutrition & Food Research reveals that
it may also benefit memory and spacial awareness as well.
http://www.medicalnewstoday.com/printerfriendlynews.php?newsid=249903
Why Do Women Gain Belly
Fat Easier Than Men?
A new
study conducted on mice and published in the journal Diabetes has revealed that high fat diets set off chemical reactions
in female mice. This discovery could explain why it is easier for women to store fat in their abdomen area than men. The trial
also touched base on what causes women to gain more fat in their bellies after menopause.
The experts explained
a process in female mice which begins with an enzyme being activated and ending when visceral fat forms. This type of fat builds up around internal organs and is associated with an increased risk of cancer, type 2 diabetes
and heart disease.
Although the enzyme performs many tasks, one involves producing a strong hormone
which pushes the visceral fat cells to form. Vitamin A is the main source for this hormone.
http://www.medicalnewstoday.com/printerfriendlynews.php?newsid=249908
Normal Weight People With Belly Fat More Likely
To Die
A person of normal body weight who has excess belly fat is more likely to die
prematurely than an obese person with a fair spread of fat around the body, researchers from the Mayo Clinic, Rochester,
Minn. explained at the European Society of Cardiology Congress 2012 in Munich, Germany. Dr. Francisco Lopez-Jimenez said that
people with a high waist-to-hip ratio, i.e. those with big bellies, but whose BMI (body mass index) are of normal weight,
are more likely to die from a cardiovascular event or any cause than anybody else.
The researchers explained
that health care professionals have always known that having central obesity - big bellies - is bad for the health. However,
nobody was sure what effect having a large stomach might have on people whose body weight is normal for their height and age.
Several studies this year have shown that smaller waist sizes are linked to better health. Researchers from Cass Business
School, City University, London, UK, revealed that if your waist
is less than half your height, you will probably live longer.
Dr. Lopes-Jimenez said:
"We
knew from previous research that central obesity is bad, but what is new in this research is that the distribution of the
fat is very important even in people with a normal weight. This group has the highest death rate, even higher than those who
are considered obese based on body mass index. From a public health perspective, this is a significant finding."
Scientists from Imperial College London and the
German Institute of Human Nutrition showed that large waists
almost double premature death risk.
Dr. Lopes-Jimenez and team gathered and analyzed data on 12,785 adults from a representative sample of
the American population; the Third National Health and Nutrition Examination Survey. Their average age was 44 years and 47.4%
of them were men.
This database had details on each individual's hip measurement, waist size, height, weight,
socioeconomic status, illnesses, etc. They matched baseline data with the National Death Index to make calculations on lifespans
and reasons for early death.
By using BMI (body mass index) details, they divided the people into three categories:
normal, overweight and obese. They divided waist-to-hip ratios into normal and high. They took into account factors which
might affect their results, such as baseline BMI, dyslipidemia, diabetes, high blood pressure, smoking, race, sex and age.
They did not include people with COPD (chronic obstructive pulmonary disease) or cancer.
Over a follow-up period
of 14.3 years, there were 2,562 deaths - 1,138 of them as a result of a cardiovascular problem.
The researchers found that people of normal weight with central obesity:
· were 2.75 times more likely to have a
cardiovascular death, than normal weight people without central obesity
·
were 2.08 times more likely to die from any cause, than normal weight people without central obesity
Karine Sahakyan, M.D., Ph.D., who was also involved in the
study, said:
"The high risk of death
may be related to a higher visceral fat accumulation in this group, which is associated with insulin resistance and other
risk factors, the limited amount of fat located on the hips and legs, which is fat with presumed protective effects, and to
the relatively limited amount of muscle mass."
Dr. Lopez-Jimenez explained that it is important for people to know that a normal BMI does not
necessarily mean that your risk of heart disease is low. What matters is where the fat is. This can be better determined if
you work out your waist-to-hip ratio, even if your body weight is normal for your height and age, he added.
A report
by English health charity, Nuffield Health, revealed that larger waist
sizes in women not only increased their risk of cardiovascular diseases, but also cancer.
What is waist-to-hip ratio?
Your waist-to-hip ratio is the measurement of
your waist divided by the measurement of your hips. The waist is measured just above the navel (belly button), and the hips
at their widest point.
A woman with a 28-inch waist and 36-inch hips will have a WHR (waist-to-hip ratio) of 28
divided by 36 = 0.77. Below are examples of male and female WHRs and how they might affect their health.
Female
WHR
· Less than 0.8 - low risk of
cardiovascular health problems
· 0.8 to 0.89 - moderate risk
of cardiovascular health problems
·
0.9 or over - high risk of cardiovascular problems
Male WHR
·
Less than 0.9 - low risk of cardiovascular health problems
·
0.9 to 0.99 - moderate risk of cardiovascular health problems
·
1 or over - high risk of cardiovascular problems
Experts say that if BMI as a predictor of cardiovascular related deaths
were replaced by WHR, many more people would be included in the high-risk group.
http://www.medicalnewstoday.com/printerfriendlynews.php?newsid=249622
Sleep Problems May
Be Early Indication Of Alzheimer's Disease
According to a team of researchers at Washington University School of Medicine,
one of the first signs of Alzheimer's disease is sleep disruptions.
The finding came from a mouse experiment
which showed that the regular sleep-wake cycle is seriously disrupted when the earliest indicators of Alzheimer's plaques
become visible in the brain.
David M. Holtzman, M.D., head researcher, the Andrew B. and Gretchen P. Jones Professor
and head of Washington University's Department of Neurology, explained:
"If sleep abnormalities begin this early in the course of human Alzheimer's disease,
those changes could provide us with an easily detectable sign of pathology. As we start to treat Alzheimer's patients
before the onset of dementia, the presence or absence of sleep problems may be a rapid indicator of whether the new treatments
are succeeding."
Problems sleeping was first linked to Alzheimer's in Holtzman's laboratory where sleeping mice were genetically
changed to develop Alzheimer's plaques when they grew older.
When healthy young mice are awake, brain levels
of a key element of the plaques naturally rise, but drop after they fall asleep, according to Holtzman's research in 2009.
The speed of development of the plaques increased when the mice were deprived of sleep because it disrupted this cycle.
Randall Bateman, M.D., co-author and the Charles F. and Joanne Knight Distinguished Professor of
Neurology at Washington University, studied similar fluctuation levels of the plaque component, a protein called amyloid beta,
that was identified in the cerebrospinal fluid of healthy individuals.
The current study, led by Jee Hoon Roh,
M.D., Ph.D., a neurologist and postdoctoral fellow in Holtzman's laboratory, has evidence that the natural rising and
falling in amyloid beta levels stop in both mice and humans when the initial signs of brain plaques come into sight.
"We suspect that the plaques are pulling in amyloid beta, removing it from the processes that would normally clear
it from the brain," Holtzman said.
Research showed that when Alzheimer's plaques start appearing in the
nocturnal animals' brains, their normal sleep time of 40 minutes during every hour of daylight is reduced to 30 minutes
per hour.
A vaccine against amyloid beta was given to a new group of mice with the same genetic alterations in
other to prove there was a direct link between changes in sleep and the protein.
Brain plaques were never seen
in these mice as they aged, their sleeping behaviors stayed the same, and the amyloid beta levels in the brain continued with
its regular fluctuations.
Scientists believe it may be possible that patients who have not yet developed any problems
with memory, but have plaques in the brain, or other indicators of the disease, are experiencing sleep problems. They are
currently conducting research to determine if their theory is correct.
Holtzman concluded: "If these sleep
problems exist, we don't yet know exactly what form they take- reduced sleep overall or trouble staying asleep or something
else entirely. But we're working to find out."
http://www.medicalnewstoday.com/printerfriendlynews.php?newsid=249909
Patients Taking Antihypertensive Drugs Show Increase in Lip Cancer
Hydrochlorothiazide, HCTZ-triamterene, and nifedipine were associated with a higher incidence of
lip cancer.
Cancer
of the lip (i.e., of the vermillion border, commissure, and labial mucosa) is a rare malignancy (yearly incidence in the U.S.,
0.7/100,000 persons). Usually occurring on the lower lip, this cancer is much less common in the dark-skinned, suggesting
that sun exposure is a major causative factor. Prompted by epidemiologic studies that linked some antihypertensive medications
with cutaneous squamous cell carcinomas (SCCs; presumably through photosensitization), investigators looked for an association
with lip cancer as well.
They reviewed more
than 13 years of pharmacy records from a large HMO and identified 712 cases of lip cancer among non-Hispanic whites who were
not HIV-positive or organ transplant recipients at diagnosis. They compared these cases with 22,904 matched controls without
lip cancer. The hypertension drugs hydrochlorothiazide (HCTZ), HCTZ-triamterene, and nifedipine were associated with a higher
incidence of lip cancer; the relative risk for HCTZ users was 2.2 (odds ratio, 1.76–2.79). As expected, lip cancer was
also associated with smoking, but the higher risk in HCTZ, HCTZ-triamterene, and nifedipine users remained after multivariable
analysis. Lisinopril recipients had no increased lip cancer incidence, indicating that risk was drug related rather than hypertension
related. The likelihood of developing lip cancer correlated positively with duration of treatment with these drugs. Those
with at least 5 years of HCTZ treatment had a fourfold increase in lip cancer.
http://dermatology.jwatch.org/cgi/content/full/2012/830/1?q=topic_stroke
Endocrine Society Releases Guidelines
on Managing Hypertriglyceridemia
The Endocrine Society has published
new guidelines on diagnosing and managing hypertriglyceridemia in the Journal of Clinical Endocrinology and Metabolism.
Among the recommendations:
- All adults should be screened for elevated triglyceride levels at least every 5 years as part of a lipid
panel.
- Diagnosis should
be based on fasting triglyceride levels.
- Medications and endocrine conditions should be ruled out as potential causes of elevated levels.
- For patients with primary hypertriglyceridemia, clinicians should
assess other cardiovascular risk factors and family history.
- Mild-to-moderate hypertriglyceridemia (triglycerides of 150-999 mg/dL) should
initially be managed with lifestyle therapy.
- For patients with severe hypertriglyceridemia (1000 mg/dL or higher), a fibrate
should be the first-line therapy.
Journal of Clinical Endocrinology and Metabolism
article
USPSTF Reaffirms Its Recommendation Against Ovarian Cancer Screening
The U.S. Preventive Services Task Force has officially reaffirmed its 2004 recommendation against screening
asymptomatic women for ovarian cancer. Published in the Annals of Internal Medicine, the statement concludes that
"there is at least moderate certainty" that the potential harms of screening outweigh any possible benefit.
The recommendation
does not apply to women with genetic mutations known to increase ovarian cancer risk.
Writing in Journal
Watch Women's Health, Andrew Kaunitz writes: "Patients regularly ask if they should be screened for ovarian
cancer. Consistent with its previous guidance, the USPSTF's answer remains an unqualified no."
Annals of Internal Medicine article
Preoperative Hyponatremia May Heighten Mortality Risk
The presence of even
mild hyponatremia before surgery is associated with increased perioperative mortality, according to a cohort study in the
Archives of Internal Medicine.
Nearly 1 million U.S. adult patients in a surgical-quality registry had
their sodium levels measured within 90 days before surgery. About 8% of patients had hyponatremia (defined as a serum sodium
level under 135 mEq/L), with most of these being only mildly hyponatremic (values ranging from 130 to 134 mEq/L).
The study's primary
outcome, mortality within 30 days after surgery, was higher in those with hyponatremia than in those with normal sodium levels
(5.2% vs. 1.3%); the difference remained significant even after adjustment for other risk factors such as smoking and functional
health status.
Editorialists comment that the findings are not surprising, given the comorbidities associated with
hyponatremia. They say it remains an open question whether elective surgery should be postponed in the face of mild hyponatremia,
"but the diagnosis should contribute to the informed consent process."
Archives of Internal Medicine article
Salt Intake
in Kids Associated with Hypertension
Increased sodium intake among
children and adolescents is associated with greater risk for hypertension — significantly so among the overweight and
obese — according to a Pediatrics study.
Researchers
studied some 6200 participants in U.S. NHANES surveys taken between 2003 and 2008; all were between the ages of 8 and 18,
and about one third were overweight or obese. Mean sodium consumption was roughly 3400 mg/day, as determined by dietary recalls.
(National guidelines call for intake under 2300 mg in children.)
Mean systolic blood pressures rose with increasing quartiles of sodium consumption. Higher levels of sodium intake were
significantly associated with pre-high blood pressure and high blood pressure among the overweight and obese, but not normal-weight
participants.
The authors note that on average, these children
consumed about as much sodium as adults. They point out that given the observational nature of their study, "a large
randomized controlled trial would be needed" to confirm the results.
Pediatrics article
Which Elders
with Systolic Hypertension Should We Treat?
Those with fast walking speeds reap more benefit.
Control of systolic hypertension in elders is difficult and often is inadequate. Treating
healthy octogenarians was beneficial in one study (JW Gen Med Apr 17 2008), but outcomes in more frail or sicker patients are unclear. U.S. researchers
used walking speed as a measure of frailty to classify 2340 older patients (mean age, 74; 50% with systolic hypertension)
as slow or fast walkers based on a threshold of 0.8 meters/second (about 75 feet in 30 seconds).
During 7 years of follow-up, 589 patients died: roughly 70 patients per 1000 person-years
among slow walkers and 24 per 1000 person-years among fast walkers. In analyses adjusted for several demographic and clinical
parameters, mortality among slow walkers did not differ by systolic hypertension status; however, among fast walkers, mortality
was 35% higher in those with systolic hypertension. No association was found between mortality and diastolic hypertension
in either fast or slow walkers.
Medline abstract
Psychotropic Drug Use Associated with Increased
Risk for Car Crashes
Antidepressants,
benzodiazepines, and so-called "Z-drugs" such as zolpidem (Ambien) and zaleplon (Sonata) are associated with increased
risk for motor vehicle accidents, according to a case-control study in the British Journal of Clinical
Pharmacology.
Using registry and claims data from Taiwan, researchers
assessed use of psychotropic drugs among 5200 people who were drivers during motor vehicle accidents and 31,000 matched controls
who were not in accidents.
Relative to nonusers, the risk
for motor vehicle accidents was higher among patients who had taken the following classes of drugs within the previous month:
antidepressants (adjusted odds ratio, 1.73), benzodiazepines (1.56), and Z-drugs (1.42), but not antipsychotics. Even relatively
low doses of antidepressants and benzodiazepines conferred increased risks.
The authors conclude that clinicians should "choose safer, alternative treatments and advise
patients not to drive, especially while taking medications, to minimize the risk of causing [traffic accidents] under the
influence of psychotropic medications."
British Journal of Clinical Pharmacology
article
Lacunar Stroke Does Not Justify Long-Term Dual Antiplatelet Therapy
In the SPS3 trial, clopidogrel added to aspirin
increased bleeding and mortality without providing a compensatory benefit.
The SPS3 Investigators. N Engl J Med 2012 Aug 30; 367:817
Carotid Intima–Media
Thickness for Cardiovascular Risk Assessment
In a large meta-analysis, addition of the test did not substantially improve Framingham risk classification.
Den Ruijter HM et al. JAMA 2012 Aug
22/29; 308:796
Does the Zoster Vaccine
Prevent Recurrent Shingles?
A small study suggests its short-term effect is nil.
Tseng HF et al. J Infect
Dis 2012 Jul 206:190
Growth Hormone–Releasing
Hormone for Cognition
GHRH improves cognitive performance and some endocrine values in healthy elderly people and in those with MCI.
Baker LD et al. Arch Neurol 2012 Aug
6;
Ginkgo Biloba: No-Go for Alzheimer's Prevention
Another large trial shows no benefit from ginkgo biloba extract in preventing Alzheimer disease, researchers
report in the Lancet Neurology.
Nearly 2900 older adults without
dementia who spontaneously reported memory complaints to their physicians were randomized to consume standardized ginkgo biloba
extract or placebo for 5 years. Overall, the rate of diagnosis with probable Alzheimer's did not differ significantly
between the ginkgo and placebo groups (1.2 and 1.4 cases per 100 person-years).
The authors note that a lower-than-expected Alzheimer's rate in both groups reduced the
study's power, while a Lancet Neurology editorialist concludes: "For adults aged 70 years or older with
a memory complaint who might be mildly cognitively impaired, use of [ginkgo biloba extract] does not decrease the risk of
Alzheimer's disease over 5 years."
Lancet Neurology article
What's
the Optimal HbA1c Level in Elders?
In an observational study, glycosylated hemoglobin between 8% and 9% was best.
Experienced clinicians have long recognized that tight glycemic control can be perilous
in frail older patients with type 2 diabetes. Now, an observational study addresses that concern. Researchers in San Francisco
studied 367 community-dwelling, older patients (mean age, 80) with diabetes who participated in a comprehensive adult day-care
program and were unable to live independently. Glycosylated hemoglobin (HbA1c) levels were measured at baseline,
and functional decline and death were tracked during 2 years of follow-up (during which, average HbA1c levels didn't
change much).
Analyses were adjusted for
potentially confounding variables. Compared with patients in the reference category (HbA1c levels, 7%–8%),
patients whose HbA1c levels were between 8% and 9% had a significantly lower incidence of functional decline or
death (relative risk, 0.88), and those with HbA1c levels <7% had a nearly significant higher incidence of functional
decline or death. Overall, the relation between HbA1c level and functional decline or death was somewhat U-shaped,
with the best outcomes among patients in the 8% to 9% range. These basic patterns were noted both among patients who took
only oral antidiabetic drugs and those who took insulin.
Sugar-Sweetened Soft Drinks Contribute Significantly to Weight Gain
Three New England Journal of Medicine studies on the consumption of sugar-sweetened
beverages suggest that the drinks have an important role in the risk for obesity.
One study, in a large cohort of initially nonobese adults, looked at patterns of drink consumption
and their relation to subjects' genetic predisposition to obesity. Researchers found that incident obesity increased with
increasing drink consumption within the same level of genetic risk; similarly, obesity increased with increasing genetic risk
within the same level of consumption.
Two other studies examined the
effects of replacing sugar-sweetened drinks with sugar-free drinks, one in normal-weight children and the other in adolescents
who were overweight or obese. Among normal-weight children, those randomized to one masked sugar-free drink/day for 18 months
gained significantly less weight and body fat, compared with those randomized to a sugar-containing drink. Among overweight
adolescents, a 1-year intervention aimed at reducing sugary drink consumption lowered gains in BMI at 1 year, but not at 2
years, relative to controls.
An editorialist says that the
studies "provide a strong impetus to develop recommendations and policy decisions to limit consumption of sugar-sweetened
beverages."
NEJM article on genetic risks for obesity (Free)
NEJM article on drinks in normal-weight kids (Free)
NEJM article on drinks in overweight kids (Free)
NEJM editorial
Which Is Worse, Hepatitis
B or Hepatitis C?
Chronic hepatitis B infection was associated with higher liver-related mortality.
Chronic hepatitis B and chronic hepatitis C virus infections are both potentially fatal
conditions, but few head-to-head comparisons of clinical outcomes have been attempted.
Among almost 7000 American men included in a large prospective database of men who have
sex with men, about 5% of participants entered the study with each type of chronic hepatitis. After a median follow-up of
almost 8 years, all-cause mortality was similar in both groups, but liver-related mortality was significantly higher for those
with chronic hepatitis B infections. This finding held true for both HIV-negative and HIV-positive participants, including
those who were severely immunocompromised.
Excluding
the few men in the study who underwent treatment for hepatitis C infection did not change the pattern. However, liver-related
mortality among participants who were coinfected with hepatitis B and HIV and who were enrolled after 2002 was markedly lower
than among those who were enrolled earlier, possibly reflecting use of newer antiviral drugs that are active against both
HIV and hepatitis B virus.
Original article (Subscription may be required)
Medline abstract
Hypoglycemia Associated with Death in Critically
Ill Patients
Moderate-to-severe hypoglycemia is tied to an increased
risk for death among patients in the ICU, according to a study in the New England Journal of Medicine.
As part of the NICE-SUGAR trial, roughly 6000 ICU patients were randomized to intensive or
conventional glucose control. Nearly half of all patients experienced moderate hypoglycemia (41–70 mg/dL), and 4% had
severe hypoglycemia (40 mg/dL or less); the majority of these patients were in the intensive control group. The primary outcome
— death within 90 days — was more frequent among those with severe hypoglycemia (35%) or moderate hypoglycemia
(29%) than among those with no hypoglycemia (24%).
The authors conclude that "it
would seem prudent to ensure that strategies for managing the blood glucose concentration in critically ill patients focus
not only on the control of hyperglycemia but also on avoidance of both moderate and severe hypoglycemia."
NEJM article
Newer Oral Anticoagulants Associated with 'Dramatic Increase' in Bleeding After ACS
When used to prevent thrombotic events after an acute coronary syndrome, the newer oral
anticoagulants (for example, apixaban, dabigatran, and rivaroxaban) are associated with increased rates of major bleeding
that offset their antithrombotic benefit, according to an Archives of Internal Medicine meta-analysis.
Researchers examined
seven randomized controlled trials comprising over 30,000 patients who were hospitalized with ACS and received antiplatelet
therapy. Compared with placebo recipients, those on new-generation oral anticoagulants had "a dramatic increase in major
bleeding events." Significant (but moderate) reductions in the risks for stent thrombosis and other ischemic events were
seen, but there was no significant effect on overall mortality.
An editorialist concludes that routine use of these drugs
in patients with ACS "is unwarranted."
Archives of Internal Medicine article
Which Elders with Systolic Hypertension Should We Treat?
Those
with fast walking speeds reap more benefit.
Control of systolic hypertension in elders is difficult and often is inadequate. Treating
healthy octogenarians was beneficial in one study (JW Gen Med Apr 17 2008), but outcomes in more frail or sicker patients are unclear. U.S. researchers
used walking speed as a measure of frailty to classify 2340 older patients (mean age, 74; 50% with systolic hypertension)
as slow or fast walkers based on a threshold of 0.8 meters/second (about 75 feet in 30 seconds).
During 7 years of follow-up, 589 patients died: roughly 70 patients per 1000 person-years
among slow walkers and 24 per 1000 person-years among fast walkers. In analyses adjusted for several demographic and clinical
parameters, mortality among slow walkers did not differ by systolic hypertension status; however, among fast walkers, mortality
was 35% higher in those with systolic hypertension. No association was found between mortality and diastolic hypertension
in either fast or slow walkers.
Medline abstract
Elevated Rheumatoid
Factor Is Associated with Excess Risk for Developing RA
In people without clinical rheumatoid arthritis, levels >25
IU/mL were associated with high future risk.
Nielsen SF et al. BMJ 2012 Sep 6; 345:e5244
Simard JF and Holmqvist M. BMJ
2012 Sep 6; 345:e5841
CAC
Improves Cardiovascular Risk Classification Among Intermediate-Risk Patients
Adding coronary artery calcium score to Framingham risk score was superior to FRS alone.
Yeboah J et al. JAMA 2012 Aug 22/29;
308:788
Does an Episode of
Shingles Portend Cancer?
Cancer risk was not higher in a population-based study.
Wang Y-P et al. CMAJ 2012 Sep 17
Sports and Energy Drinks Erode Tooth Enamel
In laboratory simulations, energy drinks eroded twice as much tooth enamel as sports drinks.
Jain P et al. Gen Dent 2012 May/Jun
60:190
Are Organic Foods More
Nutritious Than Conventional Foods?
This systematic review does not support the common belief that organic
foods are more nutritious, but evidence suggests they reduce exposure to pesticides and multiresistant bacteria.
Smith-Spangler C et al. Ann
Intern Med 2012 Sep 4; 157:348
White or Whole Grain: Does Glycemic
Index Matter During Pregnancy?
Adherence to a low-glycemic–index diet curbed maternal weight gain but did not lower incidence
of neonatal macrosomia.
Fetal macrosomia is intimately tied to the obesity epidemic: Maternal obesity raises risk for fetal macrosomia,
which in turn is a risk factor for obesity later in life. Investigators at the National Maternity Hospital in Dublin conducted
a randomized, controlled trial of a low-glycemic–index diet and its effects on neonatal macrosomia and maternal outcomes
in 800 women with prior macrosomic deliveries but no histories of gestational diabetes. Participants were randomized during
early pregnancy to receive dietary education (with a special focus on glycemic index) or routine prenatal care.
Compared with women in the control group, those in the intervention group achieved lower
dietary glycemic indexes, gained less weight during pregnancy (mean difference, 1.3 kg; P=0.01), and were less likely
to experience glucose intolerance. Although a significant proportion of women in each group exceeded recommended gestational
weight gain goals, women in the intervention group were less likely to do so (38% vs. 48%; P=0.01). However, neither
mean birth weight nor incidence of macrosomia differed between groups. Rates of preterm or cesarean delivery also did not
differ.
Medline abstract
Benzodiazepines Tied to Dementia in Elders
Benzodiazepine drugs are associated with increased risk for dementia, according to a
BMJ study.
The study included nearly
1100 community-dwelling, older adults in France who were free of dementia; 9% were considered new users of benzodiazepines
— that is, they began using the drugs after the third year of follow-up.
During the next 15 years, dementia was diagnosed significantly more often in new benzodiazepine
users than in nonusers (32% vs. 23%). After adjustment for confounders such as age, diabetes, and depression, new users had
a 60% increased risk for dementia. A complementary, nested case-control analysis found a similar increase in risk.
The researchers argue against the idea that benzodiazepine use is simply a marker for
other conditions (e.g., anxiety) that are linked to dementia — for example, the association between the drugs and dementia
increased after 7 years of use. However, they acknowledge that such a theory cannot be "entirely ruled out."
BMJ article
Low Blood Pressure Isn't
Associated with Lower Mortality in Patients with Newly Diagnosed Diabetes
Type
2 diabetic patients whose blood pressure was <110/75 had excess risk for mortality at 3.5 years.
An American Diabetes Association guideline recommends that "most patients with diabetes" receive
treatment to reach a systolic blood pressure (SBP) target of <130 mm Hg (although exceptions are allowed for "higher
or lower SBP targets" based on patients' characteristics and treatment responses) and a diastolic BP (DBP) target
of <80 mm Hg (Diabetes Care 2012; 35 (Suppl
1):S11). Little evidence, however,
supports these recommendations. In this retrospective study, investigators used the U.K. General Practice Research Database
to examine the effects of SBP and DBP on all-cause mortality in 126,000 adults with newly diagnosed type 2 diabetes.
BP was determined during the first year after diagnosis of diabetes. After median follow-up of 3.5 years,
20% of patients had died. In patients with cardiovascular (CV) disease, those whose SBP was lower than 110 mm Hg were significantly
more likely to die than were those whose SBP was 130 to 139 mm Hg (hazard ratio, 2.8); mortality among patients with SBP of
110 to 129 mm Hg was similar to that among patients with SBP of 130 to 139. Participants whose DBP was 70 to 74 mm Hg and
those whose DBP was <70 mm Hg were significantly more likely to die than were those whose DBP was 80 to 84 mm Hg (HRs,
1.3 and 1.9, respectively). Similar results were found in patients without CV disease.
CONCLUSION:
Blood pressure
below 130/80 mm Hg was not associated with reduced risk of all cause mortality in patients with newly diagnosed diabetes,
with or without known cardiovascular disease. Low blood pressure, particularly below 110/75 mm Hg, was associated with an
increased risk for poor outcomes.
Medline abstract
Vitamin D3 May Reduce Body Fat
CONCLUSION:
Among healthy overweight and obese women, increasing 25(OH) D concentrations
by vitamin D3 supplementation led to body fat mass reduction.This trial is registered at clinicaltrials.gov as NCT01344161.
http://worldhealth.net/forum/thread/98901/vitamin-d3-may-reduce-body-fat/?page=1#post-98901
Red wine may be key to longevity & weight loss
A new study suggests that could red wine could decrease your appetite, facilitate weight
loss and prevent diabetes
According to the findings published in the Journal of Aging, red wine could help you
live longer. Resveratrol, a compound found in red wine caused honeybees to decrease their food intake and live longer, while
in mice it prevented obesity and diabetes. Some research shows that resveratrol could be linked to a reduced risk of inflammation
and blood clotting.
A team of scientists from Arizona State University, the Norwegian University of Life Sciences
and Harvard Medical School conducted a series of experiments to test the effects of resveratrol on the lifespan, learning
ability and food perception in honeybees. Their research has confirmed that this compound extends the lifespan of honey bees
by 33 to 38 percent. The research also suggests that resveratrol changes the decisions that bees make about food by triggering
a “moderation effect” when they eat.
“For the first time, we conducted several tests on the
effects of resveratrol by using the honey bee as a model. We were able to confirm that under normal living conditions, resveratrol
lengthened lifespan in honey bees,” said Brenda Rascon, an ASU alumnus and doctoral student with Gro Amdam, an associate
professor in ASU’s School of Life Sciences and the Norwegian University of Life Sciences.
Free radicals,
often released during stressful conditions, are believed to cause damage to cells and have an effect on how we age. Though
resveratrol is an antioxidant, it did not, however, diminish the damaging effects of free radicals. It did not prove to extend
lives of bees living under stressful conditions. Yet, since the bees tested with the compound were living longer, researchers
wanted to know what caused them to live longer.
“Because what we eat is such an important contributor to
our physical health, we looked at the bees’ sensitivity to sugar and their willingness to consume it. Bees typically
gorge on sugar and while it’s the best thing for them, we know that eating too much is not necessarily a good thing,”
said Amdam. Interestingly, the research team discovered that bees given the compound were less sensitive to sugar. The bees
changed their perception about food.
Finally, they measured how much food the bees would consume if given the opportunity
to eat as much sugar water as they possibly could. ”Surprisingly, the bees that received the drug decreased their food
intake,” said Rascon. ”The bees were allowed to eat as much as they pleased and were certainly not starving –
they simply would not gorge on the food that we know they like. It’s possible that resveratrol may be working by some
mechanism that is related to caloric restriction – a dietary regimen long known to extend lifespan in diverse organisms,”
he added.
http://worldhealth.net/forum/thread/98898/red-wine-may-be-key-to-longevity-weigh/?page=1#post-98898
Olive Oil May Reduce Cardiovascular Risk by Boosting Endothelial Function
New research suggests that supplementing the diet with olive oil may help to reduce cardiovascular risk by
improving the function of the endothelial cells that line the blood vessels. Researchers from the Mayo Clinic and College
of Medicine and from the Department of Pharmaceutical Sciences at the University of Florence (Italy), investigated the effects
of supplementing the diet with 30 ml/day of olive oil (providing 340 mg/kg polyphenols) on endothelial function. Eighty-two
people with atherosclerosis participated in the double-blind, randomized, 4-month long trial, and 52 participants completed
the study. Results showed that olive oil consumption “significantly improved endothelial function”. A “significant
reduction in inflammatory parameters” was also observed. The researchers concluded: “Supplementation with olive
oil seems a reasonably easy and relatively cheap dietary measure to improve the endothelial function and perhaps favorably
alter the progression of atherosclerotic disease, particularly in patients with already markedly impaired endothelial function.”
http://worldhealth.net/news/olive-oil-may-reduce-cardiovascular-risk-boosting/
Acai Berry
Increases Fruit fly Lifespan
A commercially available acai berry product has been found to significantly
lengthen the lifespan of fruit flies.
Cup of Cocoa Combats Cognitive
Decline
Rich in flavanols, cocoa consumption lowers insulin resistance and blood
pressure, while boosting cognitive functions.
Eat Smart to Avoid Stroke
Systematic review reaffirms the benefits of increased dietary consumption
of fruits and vegetables to help reduce a person's risk of stroke.
Cocoa & Green Tea Compounds
Counter Inflammation
Rich in a variety of antioxidants, cocoa and green tea extracts help to reduce
markers of oxidative stress and inflammation, in overweight men and women.
Resveratrol Stabilizes Blood
Sugar Levels
Supplementation with resveratrol, a bioactive polyphenol found in grapes
and red wine, improves glycemic control as well as glycated hemoglobin (HbA1c) levels.
Dried Apples Help to Reduce
Cholesterol
Daily consumption of dried apples for six months lowers total cholesterol
by 13%, and LDL ("bad") cholesterol by 24%, among postmenopausal women.
Strawberry
Compounds May Protect the Skin
Strawberry extract added to skin cell cultures acts as a protector against
ultraviolet radiation, as well as increasing its viability and reducing damage to DNA
Potential for Curry Spice Compound
as Alzheimer’s Treatment
Curcumin, the spice compound that gives curry its yellow color and pungent
flavor, is emerging as a prime candidate as a natural treatment for Alzheimer's.
Grape Powder
May Help to Counter Metabolic Syndrome
Supplementation with a polyphenol-rich grape powder reduces inflammatory
markers involved in cellular damage.
Wild Blueberries
May Decrease Cardiovascular Disease Risk
Consuming juice from wild blueberries helps to protect DNA from damage, thereby
potentially decreasing a person's risk of cardiovascular disease.
30 Minutes
Exercise Equally Effective as 60 Minutes for Weight Loss
New research suggests that exercising for just 30 minutes is as effective
for weight loss as a whole hour.
Heart Attack Ups Spouses Risk
of Depression, Anxiety, and Suicide
Spouses of people who have a sudden heart attack are at increased risk of
depression, anxiety, and suicide, even if their partner survives.
Olive Oil May Reduce Cardiovascular
Risk by Boosting Endothelial Function
Regular consumption of olive oil may help to reduce cardiovascular risk by
improving the function of cells that line the blood vessels.
Compound Found in Heat-Processed
Food Linked to Diabetes
Exposure to a compound produced when food is cooked with dry heat has been
linked to the development of abdoinal obesity, and type 2 diabetes in mice.
Green Tea
Consumption Linked to Weight Loss and Reduction in Waist Circumference
Drinking three cups of green tea each day shown to help elderly people with
metabolic syndrome lose weight and trim their waistline.
Acai Berry
Increases Fruit fly Lifespan
A commercially available acai berry product has been found to significantly
lengthen the lifespan of fruit flies.
Vitamin D Supplementation Slashes
Risk of Respiratory Infection in Children
Study results suggest that daily vitamin D supplementation can reduce the
risk of aqcuiring respiratory infections in winter.
Plastic BPA Linked to Narrowing
of the Arteries
People with severe coronary artery disease have been found to have higher-than-normal
levels of the plastic bisphenol-A (BPA) in their urine.
Eating Pan-Fried
Red Meat Ups Prostate Cancer Risk
Eating red meat that has been cooked at high temperatures has been shown
to significantly increase the risk of developing prostate cancer.
Green Tea
Polyphenol Shrinks Skin Cancer Tumors
Epigallocatechin gallate (EGCG), a polyphenol found in green tea, could prove
to be a valuable weapon in the fight against melanoma and other skin cancers.
Screening for
lipid disorder causes
Nearly one-third of patients
referred to this specialty clinic had an identifiable secondary condition plausibly contributing to their dyslipidemia. Numerous disorders were identified, with diabetes mellitus and excessive alcohol being the most
common. The American Journal of Cardiology
Higher breast cancer risk seen in older women with type 2 diabetes
An analysis in the British Journal
of Cancer revealed that postmenopausal women who had type 2 diabetes faced a 27% increased risk of breast cancer. Researchers
could not definitively explain the association, but they said hormonal changes associated with being overweight could play
a role. WebMD
Regular NSAIDs use linked to risk in heart attack patients
A study involving nearly 100,000
heart attack patients found that regular use of nonsteroidal anti-inflammatory drugs was associated with a greater likelihood
of experiencing another heart attack or dying from heart problems, regardless of gender, age and income. The findings in the
journal Circulation support previous studies, the lead researcher said. HealthDay News
Heavy alcohol drinking may raise risk of early stroke
French researchers analyzed
the drinking habits and medical records of 540 people who had a stroke caused by intracerebral hemorrhage. The study in the
journal Neurology found that 25% of them were heavy drinkers and their stroke occurred at an average age of 60, which was
14 years earlier than the average stroke age for non-heavy drinkers. HealthDay News
Stress, personality traits linked with risk of stroke
People with type A personality
traits and those who lived with chronic stress were at higher risk of suffering a stroke even after other factors were taken
into consideration, according to Spanish study in the Journal of Neurology, Neurosurgery and Psychiatry. Researchers noted
that both heart rhythm disorder and excessive daytime sleepiness were linked to higher stroke risk. WebMD
Extreme Hot, Cold Spells Increase Heart-Related Deaths
http://mnt.to/l/48pq
http://www.medicalnewstoday.com/printerfriendlynews.php?newsid=250605
New Strategies Needed To Combat Disease In Developing Countries
http://mnt.to/l/48mH
High Antioxidant
Diet Decreases Risk Of Heart Attack In Women
http://mnt.to/l/48nH
Castrated Men Live Longer
http://mnt.to/l/48pT
Therapies Aimed At Type 2 Diabetes And Kidney
Disease May Be Developed From Compound Found In Purple Corn
http://mnt.to/l/48jV
Mechanism Identified
That Leads To Diabetes, Blindness
http://mnt.to/l/48hk
http://www.medicalnewstoday.com/printerfriendlynews.php?newsid=250356
Poor Sleep Quality Linked To Resistant Hypertension
http://mnt.to/l/48nZ
Eating Yogurt May
Protect Against High Blood Pressure
http://mnt.to/l/48mx
Blood Pressure Lowered,
Cholesterol Improved By Sesame And Rice Bran Oil
http://mnt.to/l/48kx
Adherence To DASH
Diet For Lowering Blood Pressure Less Likely In African Americans
http://mnt.to/l/48kb
Shingles And Cancer Risk
http://mnt.to/l/48hg
How The Brain Evaluates Risk
http://mnt.to/l/48kH
Music And
Language Acquisition Theory
http://mnt.to/l/48jZ
Obesity Promotes Prostate Cancer By Altering Gene Regulation
http://mnt.to/l/48pK
Choline In Eggs And Meat May Influence Gene Expression From Infancy To Adulthood
http://mnt.to/l/48nQ
Sugary Drinks Linked
To Genetic Risk Of Obesity
http://mnt.to/l/48nM
Too Much Tuna Can
Cause Mercury Poisoning In Children
http://mnt.to/l/48nn
Chocolate Gorging
Linked To Opium Chemical In Brain
http://mnt.to/l/48mC
Battles Between
Steroid Receptors To Regulate Fat Accumulation
http://mnt.to/l/48mN
Obesity Epidemic
Not Due To High Fructose Corn Syrup
http://mnt.to/l/48jF
Risk Of Diabetes
Substantially Reduced By Bariatric Surgery
http://mnt.to/l/48js
Gastric Bypass Cuts
Diabetes, Cardiovascular, Health Risks
http://mnt.to/l/48jX
Adequate Sleep
Helps Weight Loss
http://mnt.to/l/48hf
Gabapentin for
Refractory Chronic Cough?
Patients with hypersensitive central cough
reflex responded well to 10 weeks of therapy.
Ryan NM et al. Lancet 2012 Aug 28;
"Safe" Blood
Lead Levels Are Associated with Gout
Even at levels
well below 25 µg/dL, gout incidence rose as blood lead levels rose.
Krishnan E et al. Ann Intern Med 2012 Aug 21; 157:233
Kidney Stones Are Associated
with Excess Risk for CKD
Chronic kidney
disease was more common in people with multiple kidney stone episodes.
Alexander RT et al. BMJ 2012 Aug 30; 345:e5287
AAP Strongly Discourages Recreational
Use of Trampolines
Pediatricians should advise children and their parents
against recreational use of trampolines, pointing out that various safety measures have not successfully reduced injury rates,
according to a policy statement from the American Academy of Pediatrics published in Pediatrics.
In 2009, the rate of trampoline-associated injuries was 160 per 100,000 among 5- to 14-year-olds,
the AAP notes. About three fourths of injuries occurred when more than one person was on the trampoline at the same time,
with small children particularly at risk.
For families who continue to
use trampolines, the AAP makes a series of recommendations, including:
- Only one person at a time should use a trampoline.
- Trampolines should be equipped with protective padding.
- Somersaults and flips should not be allowed.
- An adult willing to enforce safety rules should always be present.
- Homeowners should check whether their insurance policies cover trampoline-associated
claims.
Pediatrics article
Does 'Organic' Really = 'Better'?
There's little
evidence that organic foods are more nutritious than conventional ones, according to a meta-analysis in the Annals of
Internal Medicine. Organic foods may, however, reduce exposure to pesticides and resistant bacteria.
The analysis included
17 studies that compared organic diets with conventional diets in humans, and 223 studies that compared nutrient and contaminant
levels in organic versus conventional foods. Overall, the researchers did not find "robust evidence" that organic
foods are more nutritious: Vitamin and nutrient levels were generally similar in both types of foods, although organic items
seemed to contain more phosphorus.
With respect to safety, organic produce was 30% less likely to be contaminated
with pesticides; similarly, conventional chicken and pork were 33% more likely to harbor antibiotic-resistant bacteria. However,
risk for contamination with pathogenic bacteria did not differ between conventional and organic foods.
The researchers conclude:
"The evidence does not suggest marked health benefits from consuming organic versus conventional foods."
Annals of Internal Medicine article
Effect of Inhaled Glucocorticoids
in Childhood on Adult Height
Background
The use of inhaled glucocorticoids for persistent asthma
causes a temporary reduction
in growth velocity in prepubertal children. The resulting decrease in attained height
1 to 4 years after
the initiation of inhaled glucocorticoids is thought not to decrease
attained adult height.
Methods
We measured adult
height in 943 of 1041 participants (90.6%) in the Childhood
Asthma Management Program; adult height was determined at
a mean (±SD) age of
24.9±2.7 years. Starting at the age of 5 to 13 years, the participants had been
randomly
assigned to receive 400 μg of budesonide, 16 mg of nedocromil, or placebo daily
for 4 to 6 years.
We calculated differences in adult height for each active treatment
group, as compared with placebo, using
multiple linear regression with adjustment
for demographic characteristics, asthma features, and height at trial entry.
Results
Mean adult height
was 1.2 cm lower (95% confidence interval [CI], −1.9 to −0.5) in
the budesonide group than in the placebo
group (P = 0.001) and was 0.2 cm lower
(95% CI, −0.9 to 0.5) in the nedocromil group than in the placebo
group (P = 0.61).
A larger daily dose of inhaled glucocorticoid in the first 2 years was associated with
a lower adult height
(−0.1 cm for each microgram per kilogram of body weight)
(P = 0.007). The reduction in adult height in the budesonide
group as compared with
the placebo group was similar to that seen after 2 years of treatment (−1.3 cm;
95% CI,
−1.7 to −0.9). During the first 2 years, decreased growth velocity in the budesonide
group occurred primarily
in prepubertal participants.
Conclusions
The initial decrease in attained height associated with the
use of inhaled glucocorticoids
in prepubertal children persisted as a reduction in adult height, although
the decrease was
not progressive or cumulative. (Funded by the National Heart,
Lung, and Blood Institute and the National Center for Research
Resources; CAMP
ClinicalTrials.gov number, NCT00000575.)
http://www.nejm.org/doi/pdf/10.1056/NEJMoa1203229
Pollen-Free House Plants For Hay Fever Sufferers
http://mnt.to/l/482s
http://www.medicalnewstoday.com/printerfriendlynews.php?newsid=249725
Leg Compressions May Limit Stroke Damage
http://mnt.to/l/4825
For Patients With
Lacunar Stroke, Aspirin-Clopidogrel Is No Better Than Aspirin Alone
http://mnt.to/l/47YZ
Chocolate May Lower
Your Stroke Risk
http://mnt.to/l/47YV
Death Risk Tripled
By Smoking After Stroke
http://mnt.to/l/47Yq
Scientists Pinpoint Enzyme That Fights Alzheimer's Disease
http://mnt.to/l/48jf
Vitamin C May Help Protect You Against Dementia
http://mnt.to/l/48dL
Fighting Alzheimer's Before Its Onset
http://mnt.to/l/48bY
Work Stress Increases Heart Attack Risk
By 23%
http://mnt.to/l/48fX
Exercise Helps Prevent Stress
http://mnt.to/l/48dP
Math Anxiety Causes Trouble For Students As Early As First Grade
http://mnt.to/l/48dn
Study Explains Decrease In Insulin-Producing Beta Cells In Diabetes
http://mnt.to/l/48fV
Type 2 Diabetes Linked To Breast Cancer Risk
http://mnt.to/l/48dT
Exercise Can Help Cancer Patients, But Few Oncologists Suggest It
http://mnt.to/l/47YD
Researchers Iron Out The Link Between Serum Ferritin And Diabetes
http://mnt.to/l/48bp
Not So Fast: PPAR Beta/delta Slows Insulin Secretion
http://mnt.to/l/48bg
Regulating Long-Term Memory Storage
http://mnt.to/l/48bn
Compound Interacts With Receptor In Brain That Plays Role In Neurodegenerative Processes In Alzheimer's
Disease
http://mnt.to/l/483w
Increased Dietary Fructose Linked To Elevated Uric Acid Levels And Lower Liver Energy Stores
http://mnt.to/l/48f9
Studies Shed Light On How To Reduce The Amount Of Toxins In Plant-Derived Foods
http://mnt.to/l/48dB
What Are Fish Oils? What Are Omega-3 Fats?
http://mnt.to/l/mMw
Organized High Fat Diet Changes Metabolism And Prevents Obesity
http://mnt.to/l/48cZ
Low Ghrelin - Reducing Appetite At The Cost Of Increased Stress?
http://mnt.to/l/48fq
Stay Thin By Reading Food Labels
http://mnt.to/l/48g2
Metabolism In The Brain Fluctuates With Circadian Rhythm
http://mnt.to/l/47YF
Why The Circadian Rhythm Affects Health
http://mnt.to/l/47Yv
Why Do Computer Tablets Disrupt Sleeping Patterns?
http://mnt.to/l/47XK
Aspirin May Prolong Prostate Cancer Survival
http://mnt.to/l/47YL
Factors That Regulate Size Of Cellular Fat Pools, Obesity
http://mnt.to/l/47Zj
Circadian Desynchrony May Disrupt The Systems In The Brain That Regulate Metabolism, Leading To Obesity
http://mnt.to/l/47Zb
Our Brains Make Men And Women See Things Differently
http://mnt.to/l/484S
Bright Light Therapy Improves Cognitive Performance And Mood For Healthy People
http://mnt.to/l/47YR
Restaurant Food Consumption And Satisfaction Affected By Lighting And Music In Surprising Ways
http://mnt.to/l/47ZH
Does Severe Calorie Restriction Help You Live Longer? Probably Not
http://mnt.to/l/47YT
Breast Milk Boosts Beneficial Growth Of Gut Flora
http://mnt.to/l/47Xz
Why Some Fats Are Worse Than Others
http://mnt.to/l/47X5
Obesity Can Lower Children's IQ
http://mnt.to/l/483X
Bright Light Therapy Improves Cognitive Performance And Mood For Healthy People
http://mnt.to/l/47YR
Positive News For Shingles Pain Sufferers
http://mnt.to/l/482W
Hypertension Risk Cut By Two Thirds By Leading A Healthy Lifestyle
http://mnt.to/l/47WY
The Effect Of Insulin Glargine And Fish Oil Supplements On Atherosclerosis Progression In High-Risk Patients
With Type 2 Diabetes Or Pre-Diabetes
http://mnt.to/l/47WZ
Normal Weight People With Belly Fat More Likely To Die
http://mnt.to/l/47Ym
Anti-Inflammatory Drug Proves Effective For Treating Severe Depression
http://mnt.to/l/484T
Cytomegalovirus Increases Risk Of Diabetes In Later In Life
http://mnt.to/l/47Wq
Why Does Alzheimer's Disease Affect Twice As Many Women As Men?
http://mnt.to/l/486D
Sleep Problems May Be Early Indication Of Alzheimer's Disease
http://mnt.to/l/486c
Rheumatoid Arthritis Infection Risk Identified
http://mnt.to/l/4868
A Delicate Balance: Gut Serotonin And Bone Maintenance
http://mnt.to/l/485F
Wine Has More Heart Benefits Than Vodka
http://mnt.to/l/48bQ
Vitamin D Supplements Do Not Improve Cholesterol As Previous Research Suggested
http://mnt.to/l/4855
Hypertension Poorly Controlled By 53% Of Americans
http://mnt.to/l/4867
Green Tea Improves Memory And Spacial Awareness
http://mnt.to/l/4865
Neuronal Inhibition Is Key For Memory Formation
http://mnt.to/l/487j
Even In Normal Range, High Blood Sugar Linked To Brain Shrinkage
http://mnt.to/l/484x
Soy Diet May Lessen Anxiety Effect Of BPA On Genes
http://mnt.to/l/488g
Omega 3 Could Help Improve Children's Reading Skills
http://mnt.to/l/488d
Non-Alcoholic Red Wine Lowers Blood Pressure
http://mnt.to/l/4884
Obese Teens Eat Fewer Calories Than Their Peers
http://mnt.to/l/4897
Even Small Weight Gains Raise Blood Pressure In College Students
http://mnt.to/l/487F
Why Do Women Gain Belly Fat Easier Than Men?
http://mnt.to/l/486b
'Fitness And Fatness': Not All Obese People Have The Same Prognosis
http://mnt.to/l/485v
You Can Be Overweight And Healthy, Research Suggests
http://mnt.to/l/4866
Obesity And Metabolic Syndrome Associated With Impaired Brain Function In Adolescents
http://mnt.to/l/484B
